(This story has been updated to include new information and correct a typo.)
The California rivalry continues as the San Francisco 49ers (1-1) travel south to take on the Los Angeles Rams (0-2).
Last week, the 49ers struggled in Minnesota, where former quarterback Sam Darnold excelled against his old team. The offense appeared to miss Christian McCaffrey, while the defense faced unexpected challenges. With Deebo Samuel now injured, San Francisco’s backups will need to step up.
Week 2 was particularly tough for Los Angeles. The Rams not only suffered a heavy defeat to the Arizona Cardinals but also lost star receiver Cooper Kupp to injury. It’s been a rough start, and head coach Sean McVay’s squad is in dire need of a win. According to BetMGM NFL odds, the 49ers are favored to beat the Rams. If you’re interested in betting, check out top mobile sports betting apps offering promotions for NFL games in 2024, including the ESPN BET app and Fanatics Sportsbook promo code.
If this matchup isn’t what you’re looking for, our guide to NFL betting odds, picks, and spreads provides insights for Thursday Night Football and Monday Night Football.
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Feeling lucky? Here are the best parlay bets and odds for NFL games this week. The match between Kyle Shanahan and Sean McVay is always compelling. While I believe the 49ers will recover, their injury problems—especially with Deebo Samuel expected to miss a few weeks—make betting on them to cover a large spread a risky move.
Both teams are facing significant injuries: the 49ers will be without Christian McCaffrey and Deebo Samuel, while the Rams are missing Cooper Kupp and Puka Nacua. With these challenges, it will be interesting to see who emerges victorious. Historically, the 49ers have dominated the Rams, winning nine of their last eleven matchups, including playoff games.
It’s unfortunate that so many key players are sidelined, as this game would be much more exciting at full strength. The Rams are struggling, and facing a tough defense without their top receivers will be a significant hurdle. With the game essentially being a home match for San Francisco, a comfortable victory for the 49ers seems likely.
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